Griffith Hughes, who described specimens from Barbados in The Natural History of Barbados. The grapefruit then probably originated as a naturally occurring hybrid between the two plants some time after they had been introduced there.Ī hybrid fruit, called forbidden fruit, was first documented in 1750 (along with 14 other citrus fruits including the guiney orange) by a Welshman, Rev. One story of the fruit's origin is that a certain "Captain Shaddock" brought pomelo seeds to Jamaica and bred the first fruit, which were then called shaddocks.Grapefruit: a fruit with a bit of a complex in Art Culinaire (Winter, 2007) This apparently referred to a captain who traded in the West Indies in the 17th century. maxima were present in the West Indies by 1692. One ancestor of the grapefruit was the Jamaican sweet orange (Citrus sinensis), itself an ancient hybrid of Asian origin the other was the Indonesian pomelo (C. Grapefruit originated as a natural hybrid. People taking drugs should ask their health-care provider or pharmacist questions about grapefruit and drug interactions. Typically, drugs that are incompatible with grapefruit are so labeled on the container or package insert. One whole grapefruit, or a glass of 200 ml of grapefruit juice may cause drug overdose toxicity. Each affected drug has either a specific increase of effect or decrease. If the drug is not absorbed, then not enough of it is in the blood to have a therapeutic effect. The other effect is that grapefruit can block the absorption of drugs in the intestine. On the other hand, some drugs must be broken down to become active, and inhibiting CYP3A4 may lead to reduced drug effects. If the drug's breakdown for removal is lessened, then the level of the drug in the blood may become too high or stay too long, leading to adverse effects. The action of the CYP3A4 enzyme itself is to metabolize many medications. Furanocoumarins inhibit the CYP3A4 enzyme, including the P450 enzyme family responsible for metabolizing 90% of drugs. In the first, the effect is from natural furanocoumarins such as bergamottin and 6',7'-dihydroxybergamottin, which occur in both grapefruit flesh and peel. Grapefruit and grapefruit juice have been found to interact with numerous drugs and in many cases, to result in adverse direct and/or side effects (if dosage is not carefully adjusted).
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